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Titel:

Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Journal Article
Autor(en):
Nakano, Eriko; Geisz, Andrea; Masamune, Atsushi; Niihori, Tetsuya; Hamada, Shin; Kume, Kiyoshi; Kakuta, Yoichi; Aoki, Yoko; Matsubara, Yoichi; Ebert, Karolin; Ludwig, Maren; Braun, Markus; Groneberg, David A; Shimosegawa, Tooru; Sahin-Tóth, Miklós; Witt, Heiko
Abstract:
Genetic alterations in the carboxypeptidase A1 gene (CPA1) are associated with early onset chronic pancreatitis (CP). Besides CPA1, there are two other human pancreatic carboxypeptidases (CPA2 and CPB1). Here we examined whether CPA2 and CPB1 alterations are associated with CP in Japan and Germany. All exons and flanking introns of CPA2 and CPB1 were sequenced in 477 Japanese patients with CP (234 alcoholic, 243 nonalcoholic) and in 497 German patients with nonalcoholic CP by targeted next-gener...     »
Zeitschriftentitel:
Am J Physiol Gastrointest Liver Physiol
Jahr:
2015
Band / Volume:
309
Heft / Issue:
8
Seitenangaben Beitrag:
G688-94
Sprache:
eng
Volltext / DOI:
doi:10.1152/ajpgi.00241.2015
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26316592
Print-ISSN:
0193-1857
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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