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Title:

Late proliferating and inflammatory effects on murine microvascular heart and lung endothelial cells after irradiation.

Document type:
Journal Article; Article
Author(s):
Sievert, Wolfgang; Trott, Klaus-Rüdiger; Azimzadeh, Omid; Tapio, Soile; Zitzelsberger, Horst; Multhoff, Gabriele
Abstract:
Radiotherapy of thoracic tumors increases the risk to develop cardiac diseases at later time-points. We compared time kinetics of radiation-induced changes of surface markers related to proliferation, progenitor cell development and inflammation in lung and heart microvascular endothelial cells (ECs).Mice received local thorax irradiation with a single dose of 0, 2 or 8Gy. Following magnetic bead separation and biotin-streptavidin competition, cell surface markers of isolated ECs from the lung a...     »
Journal title abbreviation:
Radiother Oncol
Year:
2015
Journal volume:
117
Journal issue:
2
Pages contribution:
376-81
Language:
eng
Fulltext / DOI:
doi:10.1016/j.radonc.2015.07.029
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26233589
Print-ISSN:
0167-8140
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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