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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Almstätter, Isabella; Mykhaylyk, Olga; Settles, Marcus; Altomonte, Jennifer; Aichler, Michaela; Walch, Axel; Rummeny, Ernst J; Ebert, Oliver; Plank, Christian; Braren, Rickmer
Titel:
Characterization of magnetic viral complexes for targeted delivery in oncology.
Abstract:
Oncolytic viruses are promising new agents in cancer therapy. Success of tumor lysis is often hampered by low intra-tumoral titers due to a strong anti-viral host immune response and insufficient tumor targeting. Previous work on the co-assembly of oncolytic virus particles (VPs) with magnetic nanoparticles (MNPs) was shown to provide shielding from inactivating immune response and improve targeting by external field gradients. In addition, MNPs are detected by magnet resonance imaging (MRI) ena...     »
Zeitschriftentitel:
Theranostics
Jahr:
2015
Band / Volume:
5
Heft / Issue:
7
Seitenangaben Beitrag:
667-85
Sprache:
eng
Volltext / DOI:
doi:10.7150/thno.10438
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25897333
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Experimentelle Onkologie und Therapieforschung
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