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Titel:

Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma.

Dokumenttyp:
Journal Article
Autor(en):
Berchtold, Sonja; Grünwald, Barbara; Krüger, Achim; Reithmeier, Anja; Hähl, Teresa; Cheng, Tao; Feuchtinger, Annette; Born, Diana; Erkan, Mert; Kleeff, Jörg; Esposito, Irene
Abstract:
Excessive matrix production by pancreatic stellate cells promotes local growth and metastasis of pancreatic ductal adenocarcinoma and provides a barrier for drug delivery. Collagen type V is a fibrillar, regulatory collagen up-regulated in the stroma of different malignant tumors. Here we show that collagen type V is expressed by pancreatic stellate cells in the stroma of pancreatic ductal adenocarcinoma and affects the malignant phenotype of various pancreatic cancer cell lines by promoting adh...     »
Zeitschriftentitel:
Cancer Lett
Jahr:
2015
Band / Volume:
356
Heft / Issue:
2 Pt B
Seitenangaben Beitrag:
721-32
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.canlet.2014.10.020
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25449434
Print-ISSN:
0304-3835
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Experimentelle Onkologie und Therapieforschung
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