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Title:

Opposing role of Notch1 and Notch2 in a Kras(G12D)-driven murine non-small cell lung cancer model.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Baumgart, A; Mazur, P K; Anton, M; Rudelius, M; Schwamborn, K; Feuchtinger, A; Behnke, K; Walch, A; Braren, R; Peschel, C; Duyster, J; Siveke, J T; Dechow, T
Abstract:
Lung cancer is the leading cause of cancer-related deaths worldwide. Recently, we have shown that Notch1 inhibition resulted in substantial cell death of non-small cell lung cancer (NSCLC) cells in vitro. New compounds targeting Notch signal transduction have been developed and are now being tested in clinical trials. However, the tumorigenic role of individual Notch receptors in vivo remains largely unclear. Using a Kras(G12D)-driven endogenous NSCLC mouse model, we analyzed the effect of condi...     »
Journal title abbreviation:
Oncogene
Year:
2015
Journal volume:
34
Journal issue:
5
Pages contribution:
578-88
Language:
eng
Fulltext / DOI:
doi:10.1038/onc.2013.592
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24509876
Print-ISSN:
0950-9232
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung
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