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Titel:

Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Beck, Philipp; Cui, Haissi; Hegemann, Julian D; Marahiel, Mohammed A; Krüger, Achim; Groll, Michael
Abstract:
Clinical application of proteasome inhibitors (PIs) is so far limited to peripheral blood cancers due to the pronounced cytotoxicity towards all cell types. Targeted delivery of PIs could permit the treatment of other cancers along with decreasing side effects. Herein we describe the first small-molecule proteasome inhibitor conjugate for targeted delivery, created by fusing PIs to a synthetic ligand of somatostatin receptors, which are highly expressed in a variety of tumors. X-ray crystallogra...     »
Zeitschriftentitel:
ChemMedChem
Jahr:
2015
Band / Volume:
10
Heft / Issue:
12
Seitenangaben Beitrag:
1969-73
Sprache:
eng
Volltext / DOI:
doi:10.1002/cmdc.201500449
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26471124
Print-ISSN:
1860-7179
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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