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Title:

Nanomagnetic activation as a way to control the efficacy of nucleic acid delivery.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Grze?kowiak, Bartosz F; Sanchez-Antequera, Yolanda; Hammerschmid, Edelburga; Döblinger, Markus; Eberbeck, Dietmar; Wo?niak, Anna; S?omski, Ryszard; Plank, Christian; Mykhaylyk, Olga
Abstract:
To explore the potential of magnetofection in delivering pDNA to primary mouse embryonic fibroblasts (PMEFs) and porcine fetal fibroblasts (PFFs) and investigate an effect of magnetic cell labeling on transfection efficacy.The formulation and a dose of the magnetic vector were optimized. The efficacy of the procedure was quantified by vector internalization, transgene expression and cell iron loading upon specific labeling with Ab-conjugated magnetic beads or non-specific labeling with MNPs.Up t...     »
Journal title abbreviation:
Pharm Res
Year:
2015
Journal volume:
32
Journal issue:
1
Pages contribution:
103-21
Language:
eng
Fulltext / DOI:
doi:10.1007/s11095-014-1448-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25033763
Print-ISSN:
0724-8741
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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