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Title:

Premetastatic niche formation in the liver: emerging mechanisms and mouse models.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Krüger, Achim
Abstract:
The liver is recognized as the target organ of metastases of almost all prominent malignancies. Its unique biology renders this organ particularly susceptible to circulating disseminated tumour cells (DTCs), and it can be assumed that very early metastasis occurs in the liver. The premetastatic niche concept may explain very early metastasis, as it defines priming of a future target organ of metastasis by factors that may already be secreted from premalignant lesions. This review shows that comp...     »
Journal title abbreviation:
J Mol Med
Year:
2015
Journal volume:
93
Journal issue:
11
Pages contribution:
1193-201
Language:
eng
Fulltext / DOI:
doi:10.1007/s00109-015-1342-7
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26400831
Print-ISSN:
0946-2716
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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