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Title:

TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Kobuch, Julia; Cui, Haissi; Grünwald, Barbara; Saftig, Paul; Knolle, Percy A; Krüger, Achim
Abstract:
The homeostasis of neutrophil granulocytes can affect the outcome of several inflammation-associated diseases including cancer. The regulation of this homeostasis is still not completely understood. We previously found that elevated systemic levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) induce an increase of neutrophils in the liver, which in turn strongly promotes liver metastasis. Here, we report that increasing systemic TIMP-1 levels were sufficient to induce neutrophilia in mic...     »
Journal title abbreviation:
Haematologica
Year:
2015
Journal volume:
100
Journal issue:
8
Pages contribution:
1005-13
Language:
eng
Fulltext / DOI:
doi:10.3324/haematol.2014.121590
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26001794
Print-ISSN:
0390-6078
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Roman Herzog Comprehensive Cancer Center
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