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Title:

Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kelwick, Richard; Wagstaff, Laura; Decock, Julie; Roghi, Christian; Cooley, Lindsay S; Robinson, Stephen D; Arnold, Hugh; Gavrilovi?, Jelena; Jaworski, Diane M; Yamamoto, Kazuhiro; Nagase, Hideaki; Seubert, Bastian; Krüger, Achim; Edwards, Dylan R
Abstract:
The ADAMTS proteinases are a family of secreted, matrix-associated enzymes that have diverse roles in the regulation of tissue organization and vascular homeostasis. Several of the 19 human family members have been identified as having either tumor promoting or suppressing roles. We previously demonstrated that decreased ADAMTS15 expression correlated with a worse clinical outcome in mammary carcinoma (e.g., Porter et al., Int J Cancer 2006; 118:1241-7). We have explored the effects of A Disinte...     »
Journal title abbreviation:
Int J Cancer
Year:
2015
Journal volume:
136
Journal issue:
4
Pages contribution:
E14-26
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.29129
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25099234
Print-ISSN:
0020-7136
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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