User: Guest  Login
Title:

Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kong, Bo; Cheng, Tao; Qian, Chengjia; Wu, Weiwei; Steiger, Katja; Cao, Jing; Schlitter, Anna Melissa; Regel, Ivonne; Raulefs, Susanne; Friess, Helmut; Erkan, Mert; Esposito, Irene; Kleeff, Jörg; Michalski, Christoph W
Abstract:
Pancreatic acinar cell carcinoma (ACC) is a rare tumor entity with an unfavorable prognosis. Recent whole-exome sequencing identified p53 mutations in a subset of human ACC. Activation of the mammalian target of rapamycin (mTOR) pathway is associated with various pancreatic neoplasms. We thus aimed at analyzing whether activation of mTOR with a concomitant loss of p53 may initiate ACC.We generated transgenic mouse models in which mTOR was hyperactivated through pancreas-specific, homozygous tube...     »
Journal title abbreviation:
Mol Cancer
Year:
2015
Journal volume:
14
Pages contribution:
212
Language:
eng
Fulltext / DOI:
doi:10.1186/s12943-015-0483-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26683340
Print-ISSN:
1476-4598
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
 BibTeX