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Title:

Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Russell, Ronan; Perkhofer, Lukas; Liebau, Stefan; Lin, Qiong; Lechel, André; Feld, Fenja M; Hessmann, Elisabeth; Gaedcke, Jochen; Güthle, Melanie; Zenke, Martin; Hartmann, Daniel; von Figura, Guido; Weissinger, Stephanie E; Rudolph, Karl-Lenhard; Möller, Peter; Lennerz, Jochen K; Seufferlein, Thomas; Wagner, Martin; Kleger, Alexander
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular oncogenic mutations and recent genetic sequencing studies have identified ataxia telangiectasia-mutated (ATM) mutations in PDAC cohorts. Here we report that conditional deletion of ATM in a mouse model of PDAC induces a greater number of proliferative precursor lesions coupled with a pronounced fibrotic reaction. ATM-targeted mice display altered TGF?-superfamily signalling and enhanced epithelial-to-mesenchyma...     »
Journal title abbreviation:
Nat Commun
Year:
2015
Journal volume:
6
Pages contribution:
7677
Language:
eng
Fulltext / DOI:
doi:10.1038/ncomms8677
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26220524
Print-ISSN:
2041-1723
TUM Institution:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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