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Title:

TLR and RLR Signaling Are Reprogrammed in Opposite Directions after Detection of Viral Infection.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hotz, Christian; Roetzer, Laurin C; Huber, Thomas; Sailer, Andreas; Oberson, Anne; Treinies, Marina; Heidegger, Simon; Herbst, Tina; Endres, Stefan; Bourquin, Carole
Abstract:
Innate immune recognition of RNA is key for the initiation of immunity in response to viral infection. Although the factors controlling the detection of viral RNA by innate immune receptors in host cells are increasingly well understood, little is known about the dynamic changes in signaling after the initial triggering of these receptors. In this study, we report that preconditioning with the synthetic dsRNA polyinosinic-polycytidylic acid [poly(I:C)], a mimetic of viral RNA, rapidly reprograms...     »
Journal title abbreviation:
J Immunol
Year:
2015
Journal volume:
195
Journal issue:
9
Pages contribution:
4387-95
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.1500079
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26392465
Print-ISSN:
0022-1767
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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