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Titel:

TLR and RLR Signaling Are Reprogrammed in Opposite Directions after Detection of Viral Infection.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Hotz, Christian; Roetzer, Laurin C; Huber, Thomas; Sailer, Andreas; Oberson, Anne; Treinies, Marina; Heidegger, Simon; Herbst, Tina; Endres, Stefan; Bourquin, Carole
Abstract:
Innate immune recognition of RNA is key for the initiation of immunity in response to viral infection. Although the factors controlling the detection of viral RNA by innate immune receptors in host cells are increasingly well understood, little is known about the dynamic changes in signaling after the initial triggering of these receptors. In this study, we report that preconditioning with the synthetic dsRNA polyinosinic-polycytidylic acid [poly(I:C)], a mimetic of viral RNA, rapidly reprograms...     »
Zeitschriftentitel:
J Immunol
Jahr:
2015
Band / Volume:
195
Heft / Issue:
9
Seitenangaben Beitrag:
4387-95
Sprache:
eng
Volltext / DOI:
doi:10.4049/jimmunol.1500079
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26392465
Print-ISSN:
0022-1767
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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