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Title:

Fingolimod induces neuroprotective factors in human astrocytes.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hoffmann, Franziska S; Hofereiter, Johann; Rübsamen, Heike; Melms, Johannes; Schwarz, Sigrid; Faber, Hans; Weber, Peter; Pütz, Benno; Loleit, Verena; Weber, Frank; Hohlfeld, Reinhard; Meinl, Edgar; Krumbholz, Markus
Abstract:
Fingolimod (FTY720) is the first sphingosine-1-phosphate (S1P) receptor modulator approved for the treatment of multiple sclerosis. The phosphorylated active metabolite FTY720-phosphate (FTY-P) interferes with lymphocyte trafficking. In addition, it accumulates in the CNS and reduces brain atrophy in multiple sclerosis (MS), and neuroprotective effects are hypothesized.Human primary astrocytes as well as human astrocytoma cells were stimulated with FTY-P or S1P. We analyzed gene expression by a...     »
Journal title abbreviation:
J Neuroinflammation
Year:
2015
Journal volume:
12
Pages contribution:
184
Language:
eng
Fulltext / DOI:
doi:10.1186/s12974-015-0393-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26419927
Print-ISSN:
1742-2094
TUM Institution:
Neurologische Klinik und Poliklinik
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