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Title:

IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis.

Document type:
journal article
Author(s):
Lee, Youjin; Mitsdoerffer, Meike; Xiao, Sheng; Gu, Guangxiang; Sobel, RaymondA; Kuchroo, VijayK
Abstract:
IL-17-producing CD4+ T cells (Th17 cells) have well-described pathogenic roles in tissue inflammation and autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE); however, the involvement of IL-21 in these processes has remained controversial. While IL-21 is an essential autocrine amplification factor for differentiation of Th17 cells, the loss of IL-21 or IL-21 receptor (IL-21R) does not protect mice from actively induced EAE. Here, we utilized a transgenic EAE mouse model...     »
Journal title abbreviation:
J Clin Invest
Year:
2015
Journal volume:
125
Journal issue:
11
Pages contribution:
-
Language:
eng
Fulltext / DOI:
doi:10.1172/JCI75933
Print-ISSN:
0021-9738
TUM Institution:
Neurologische Klinik und Poliklinik
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