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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Illert, A L; Albers, C; Kreutmair, S; Leischner, H; Peschel, C; Miething, C; Duyster, J
Title:
Grb10 is involved in BCR-ABL-positive leukemia in mice.
Abstract:
The SH2-containing adaptor protein Grb10 was first identified in a yeast screen as a new binding partner for BCR-ABL and associates with BCR-ABL in a tyrosine-dependent manner. However, its function in BCR-ABL-mediated leukemogenesis in vivo is still unknown. Here we describe an important role of Grb10 in BCR-ABL-induced leukemia by using a versatile system for efficient oncogene expression and simultaneous Grb10 knockdown from a single vector. Primary bone marrow (BM) cells coexpressing Grb10-m...     »
Journal title abbreviation:
Leukemia
Year:
2015
Journal volume:
29
Journal issue:
4
Pages contribution:
858-68
Language:
eng
Fulltext / DOI:
doi:10.1038/leu.2014.283
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25249015
Print-ISSN:
0887-6924
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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