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Titel:

The bone marrow microenvironment is a critical player in the NK cell response against acute myeloid leukaemia in vitro.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Vasold, Jochen; Wagner, Michaela; Drolle, Heidrun; Deniffel, Christian; Kütt, Alexander; Oostendorp, Robert; Sironi, Silvia; Rieger, Christina; Fiegl, Michael
Abstract:
Immune therapy for acute myeloid leukaemia (AML) has been largely disappointing. One possible explanation might lie in the microenvironment of the bone marrow, comprising cellular (e.g. mesenchymal stromal cells, MSC) and non-cellular components (e.g. hypoxia). The purpose of this study was to investigate the effects of these components in the immune response against AML in vitro. In vitro exposure of lymphocytes to hypoxia resulted in an increased expression of CD69 as an activation marker in N...     »
Zeitschriftentitel:
Leuk Res
Jahr:
2015
Band / Volume:
39
Heft / Issue:
2
Seitenangaben Beitrag:
257-62
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.leukres.2014.12.001
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25542695
Print-ISSN:
0145-2126
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Klinik für Anästhesiologie (DHM)
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