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Title:

Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells.

Document type:
Journal Article; Article
Author(s):
Ruppert, Raphael; Moser, Markus; Sperandio, Markus; Rognoni, Emanuel; Orban, Martin; Liu, Wen-Hsin; Schulz, Ansgar S; Oostendorp, Robert A J; Massberg, Steffen; Fässler, Reinhard
Abstract:
Hematopoietic stem cells (HSCs) generate highly dividing hematopoietic progenitor cells (HPCs), which produce all blood cell lineages. HSCs are usually quiescent, retained by integrins in specific niches, and become activated when the pools of HPCs decrease. We report that Kindlin-3-mediated integrin activation controls homing of HSCs to the bone marrow (BM) and the retention of activated HSCs and HPCs but not of quiescent HSCs in their BM niches. Consequently, Kindlin-3-deficient HSCs enter qui...     »
Journal title abbreviation:
J Exp Med
Year:
2015
Journal volume:
212
Journal issue:
9
Pages contribution:
1415-32
Language:
eng
Fulltext / DOI:
doi:10.1084/jem.20150269
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26282877
Print-ISSN:
0022-1007
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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