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Title:

Brain endothelial TAK1 and NEMO safeguard the neurovascular unit.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ridder, Dirk A; Wenzel, Jan; Müller, Kristin; Töllner, Kathrin; Tong, Xin-Kang; Assmann, Julian C; Stroobants, Stijn; Weber, Tobias; Niturad, Cristina; Fischer, Lisanne; Lembrich, Beate; Wolburg, Hartwig; Grand'Maison, Marilyn; Papadopoulos, Panayiota; Korpos, Eva; Truchetet, Francois; Rades, Dirk; Sorokin, Lydia M; Schmidt-Supprian, Marc; Bedell, Barry J; Pasparakis, Manolis; Balschun, Detlef; D'Hooge, Rudi; Löscher, Wolfgang; Hamel, Edith; Schwaninger, Markus
Abstract:
Inactivating mutations of the NF-?B essential modulator (NEMO), a key component of NF-?B signaling, cause the genetic disease incontinentia pigmenti (IP). This leads to severe neurological symptoms, but the mechanisms underlying brain involvement were unclear. Here, we show that selectively deleting Nemo or the upstream kinase Tak1 in brain endothelial cells resulted in death of endothelial cells, a rarefaction of brain microvessels, cerebral hypoperfusion, a disrupted blood-brain barrier (BBB),...     »
Journal title abbreviation:
J Exp Med
Year:
2015
Journal volume:
212
Journal issue:
10
Pages contribution:
1529-49
Language:
eng
Fulltext / DOI:
doi:10.1084/jem.20150165
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26347470
Print-ISSN:
0022-1007
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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