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Titel:

Manipulation of tumor metabolism for therapeutic approaches: ovarian cancer-derived cell lines as a model system.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Goetze, Kristina; Fabian, Christian G; Siebers, Andrea; Binz, Livia; Faber, Daniel; Indraccolo, Stefano; Nardo, Giorgia; Sattler, Ulrike G A; Mueller-Klieser, Wolfgang
Abstract:
Malignant transformation of cells is often accompanied by up-regulation of glycolysis-related enzymes and transporters, as well as a distortion of mitochondrial respiration. As a consequence, most malignant tumors utilize high amounts of glucose and produce and accumulate high concentrations of lactate, even in the presence of oxygen. This phenomenon has been termed 'Warburg Effect'. Here, we aimed at resolving the interrelation between tumor metabolism, reactive oxygen species, double strand DN...     »
Zeitschriftentitel:
Cell Oncol (Dordr)
Jahr:
2015
Band / Volume:
38
Heft / Issue:
5
Seitenangaben Beitrag:
377-85
Sprache:
eng
Volltext / DOI:
doi:10.1007/s13402-015-0237-5
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26288178
Print-ISSN:
2211-3428
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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