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Title:

In vivo hematopoietic Myc activation directs a transcriptional signature in endothelial cells within the bone marrow microenvironment.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Franke, Katharina; Vilne, Baiba; Prazeres da Costa, Olivia; Rudelius, Martina; Peschel, Christian; Oostendorp, Robert A J; Keller, Ulrich
Abstract:
Cancer pathogenesis involves tumor-intrinsic genomic aberrations and tumor-cell extrinsic mechanisms such as failure of immunosurveillance and structural and functional changes in the microenvironment. Using Myc as a model oncogene we established a conditional mouse bone marrow transduction/transplantation model where the conditional activation of the oncoprotein Myc expressed in the hematopoietic system could be assessed for influencing the host microenvironment. Constitutive ectopic expression...     »
Journal title abbreviation:
Oncotarget
Year:
2015
Journal volume:
6
Journal issue:
26
Pages contribution:
21827-39
Language:
eng
Fulltext / DOI:
doi:10.18632/oncotarget.5217
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26308666
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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