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Title:

Quantitative Analysis of the Association Angle between T-cell Receptor V?/V? Domains Reveals Important Features for Epitope Recognition.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Hoffmann, Thomas; Krackhardt, Angela M; Antes, Iris
Abstract:
T-cell receptors (TCR) play an important role in the adaptive immune system as they recognize pathogen- or cancer-based epitopes and thus initiate the cell-mediated immune response. Therefore there exists a growing interest in the optimization of TCRs for medical purposes like adoptive T-cell therapy. However, the molecular mechanisms behind T-cell signaling are still predominantly unknown. For small sets of TCRs it was observed that the angle between their V?- and V?-domains, which bind the epi...     »
Journal title abbreviation:
PLoS Comput Biol
Year:
2015
Journal volume:
11
Journal issue:
7
Pages contribution:
e1004244
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pcbi.1004244
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26185983
Print-ISSN:
1553-734X
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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