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Title:

Induction and repair of DNA cross-links induced by sulfur mustard in the A-549 cell line followed by a comet assay.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Jost, Petr; Svobodova, Hana; Stetina, Rudolf
Abstract:
Sulfur mustard is a highly toxic chemical warfare agent with devastating impact on intoxicated tissues. DNA cross-links are probably the most toxic DNA lesions induced in the cell by sulfur mustard. The comet assay is a very sensitive method for measuring DNA damage. In the present study using the A-549 lung cell line, the comet assay protocol was optimized for indirect detection of DNA cross-links induced by sulfur mustard. The method is based on the additional treatment of the assayed cells co...     »
Journal title abbreviation:
Chem Biol Interact
Year:
2015
Journal volume:
237
Pages contribution:
31-7
Language:
eng
Fulltext / DOI:
doi:10.1016/j.cbi.2015.05.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25986970
Print-ISSN:
0009-2797
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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