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Title:

Cks1 is a critical regulator of hematopoietic stem cell quiescence and cycling, operating upstream of Cdk inhibitors.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Tomiatti, V; Istvánffy, R; Pietschmann, E; Kratzat, S; Hoellein, A; Quintanilla-Fend, L; von Bubnoff, N; Peschel, C; Oostendorp, R A J; Keller, U
Abstract:
Cyclin-dependent kinase subunit 1 (Cks1) is a critical rate-limiting component of the Skp1-Cullin1-Skp2 (SCF(Skp2)) ubiquitin ligase that controls cell cycle inhibitor abundance. Cyclin-dependent kinase (Cdk) inhibitors (CKIs) regulate hematopoietic stem cell (HSC) self-renewal, regeneration after cytotoxic stress and tumor cell proliferation. We thus studied the role of Cks1 in HSC and in a prototypic stem cell disorder, chronic myeloid leukemia (CML). Cks1 transcript was highly expressed in Li...     »
Journal title abbreviation:
Oncogene
Year:
2015
Journal volume:
34
Journal issue:
33
Pages contribution:
4347-57
Language:
eng
Fulltext / DOI:
doi:10.1038/onc.2014.364
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25417705
Print-ISSN:
0950-9232
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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