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Title:

?-Secretase directly sheds the survival receptor BCMA from plasma cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Laurent, Sarah A; Hoffmann, Franziska S; Kuhn, Peer-Hendrik; Cheng, Qingyu; Chu, Yuanyuan; Schmidt-Supprian, Marc; Hauck, Stefanie M; Schuh, Elisabeth; Krumbholz, Markus; Rübsamen, Heike; Wanngren, Johanna; Khademi, Mohsen; Olsson, Tomas; Alexander, Tobias; Hiepe, Falk; Pfister, Hans-Walter; Weber, Frank; Jenne, Dieter; Wekerle, Hartmut; Hohlfeld, Reinhard; Lichtenthaler, Stefan F; Meinl, Edgar
Abstract:
Survival of plasma cells is regulated by B-cell maturation antigen (BCMA), a membrane-bound receptor activated by its agonist ligands BAFF and APRIL. Here we report that ?-secretase directly cleaves BCMA, without prior truncation by another protease. This direct shedding is facilitated by the short length of BCMA's extracellular domain. In vitro, ?-secretase reduces BCMA-mediated NF-?B activation. In addition, ?-secretase releases soluble BCMA (sBCMA) that acts as a decoy neutralizing APRIL. In...     »
Journal title abbreviation:
Nat Commun
Year:
2015
Journal volume:
6
Pages contribution:
7333
Language:
eng
Fulltext / DOI:
doi:10.1038/ncomms8333
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26065893
Print-ISSN:
2041-1723
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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