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Titel:

Grb10 is involved in BCR-ABL-positive leukemia in mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Illert, A L; Albers, C; Kreutmair, S; Leischner, H; Peschel, C; Miething, C; Duyster, J
Abstract:
The SH2-containing adaptor protein Grb10 was first identified in a yeast screen as a new binding partner for BCR-ABL and associates with BCR-ABL in a tyrosine-dependent manner. However, its function in BCR-ABL-mediated leukemogenesis in vivo is still unknown. Here we describe an important role of Grb10 in BCR-ABL-induced leukemia by using a versatile system for efficient oncogene expression and simultaneous Grb10 knockdown from a single vector. Primary bone marrow (BM) cells coexpressing Grb10-m...     »
Zeitschriftentitel:
Leukemia
Jahr:
2015
Band / Volume:
29
Heft / Issue:
4
Seitenangaben Beitrag:
858-68
Sprache:
eng
Volltext / DOI:
doi:10.1038/leu.2014.283
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25249015
Print-ISSN:
0887-6924
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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