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Titel:

Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-?B and JNK activation.

Dokumenttyp:
Journal Article; Article
Autor(en):
Knies, Nathalie; Alankus, Begüm; Weilemann, Andre; Tzankov, Alexandar; Brunner, Kristina; Ruff, Tanja; Kremer, Marcus; Keller, Ulrich B; Lenz, Georg; Ruland, Jürgen
Abstract:
The aggressive activated B cell-like subtype of diffuse large B-cell lymphoma is characterized by aberrant B-cell receptor (BCR) signaling and constitutive nuclear factor kappa-B (NF-?B) activation, which is required for tumor cell survival. BCR-induced NF-?B activation requires caspase recruitment domain-containing protein 11 (CARD11), and CARD11 gain-of-function mutations are recurrently detected in human diffuse large B-cell lymphoma (DLBCL). To investigate the consequences of dysregulated CA...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2015
Band / Volume:
112
Heft / Issue:
52
Seitenangaben Beitrag:
E7230-8
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.1507459112
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26668357
Print-ISSN:
0027-8424
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Klinische Chemie und Pathobiochemie
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