User: Guest  Login
Title:

Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-?B and JNK activation.

Document type:
Journal Article; Article
Author(s):
Knies, Nathalie; Alankus, Begüm; Weilemann, Andre; Tzankov, Alexandar; Brunner, Kristina; Ruff, Tanja; Kremer, Marcus; Keller, Ulrich B; Lenz, Georg; Ruland, Jürgen
Abstract:
The aggressive activated B cell-like subtype of diffuse large B-cell lymphoma is characterized by aberrant B-cell receptor (BCR) signaling and constitutive nuclear factor kappa-B (NF-?B) activation, which is required for tumor cell survival. BCR-induced NF-?B activation requires caspase recruitment domain-containing protein 11 (CARD11), and CARD11 gain-of-function mutations are recurrently detected in human diffuse large B-cell lymphoma (DLBCL). To investigate the consequences of dysregulated CA...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2015
Journal volume:
112
Journal issue:
52
Pages contribution:
E7230-8
Language:
eng
Fulltext / DOI:
doi:10.1073/pnas.1507459112
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26668357
Print-ISSN:
0027-8424
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Klinische Chemie und Pathobiochemie
 BibTeX