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Title:

MRZ-99030 - A novel modulator of A? aggregation: II - Reversal of A? oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice.

Document type:
Journal Article; Article
Author(s):
Rammes, Gerhard; Gravius, Andreas; Ruitenberg, Maarten; Wegener, Nico; Chambon, Caroline; Sroka-Saidi, Kamila; Jeggo, Ross; Staniaszek, Lydia; Spanswick, Dave; O'Hare, Eugene; Palmer, Philip; Kim, Eun-Mee; Bywalez, Wolfgang; Egger, Veronica; Parsons, Christopher G
Abstract:
?-amyloid1-42 (A?1-42) is a major endogenous pathogen underlying the aetiology of Alzheimer's disease (AD). Recent evidence indicates that soluble A? oligomers, rather than plaques, are the major cause of synaptic dysfunction and neurodegeneration. Small molecules that suppress A? aggregation, reduce oligomer stability or promote off-pathway non-toxic oligomerization represent a promising alternative strategy for neuroprotection in AD. MRZ-99030 was recently identified as a dipeptide that modula...     »
Journal title abbreviation:
Neuropharmacology
Year:
2015
Journal volume:
92
Pages contribution:
170-82
Language:
eng
Fulltext / DOI:
doi:10.1016/j.neuropharm.2014.12.037
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25637092
Print-ISSN:
0028-3908
TUM Institution:
Klinik für Anästhesiologie (DHM)
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