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Title:

A Hot-Segment-Based Approach for the Design of Cross-Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self-Assembly.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Andreetto, Erika; Malideli, Eleni; Yan, Li-Mei; Kracklauer, Michael; Farbiarz, Karine; Tatarek-Nossol, Marianna; Rammes, Gerhard; Prade, Elke; Neumüller, Tatjana; Caporale, Andrea; Spanopoulou, Anna; Bakou, Maria; Reif, Bernd; Kapurniotu, Aphrodite
Abstract:
The design of inhibitors of protein-protein interactions mediating amyloid self-assembly is a major challenge mainly due to the dynamic nature of the involved structures and interfaces. Interactions of amyloidogenic polypeptides with other proteins are important modulators of self-assembly. Here we present a hot-segment-linking approach to design a series of mimics of the IAPP cross-amyloid interaction surface with A? (ISMs) as nanomolar inhibitors of amyloidogenesis and cytotoxicity of A?, IAPP...     »
Journal title abbreviation:
Angew Chem Int Ed Engl
Year:
2015
Journal volume:
54
Journal issue:
44
Pages contribution:
13095-100
Language:
eng
Fulltext / DOI:
doi:10.1002/anie.201504973
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26336938
Print-ISSN:
1433-7851
TUM Institution:
Klinik für Anästhesiologie (DHM)
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