Alkynol natural products target ALDH2 in cancer cells by irreversible binding to the active site
Chem. Commun.
2015
51
87
15784-15787
AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control
Nature Communications
2015
6320
Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization
J. Am. Chem. Soc.
2015
137
26
8475-8483
Effective GTP-Replacing FtsZ Inhibitors and Antibacterial Mechanism of Action
ACS Chem. Biol.
2015
10
834-843
A Mass Spectrometry Platform for a Streamlined Investigation of Proteasome Integrity, Posttranslational Modifications, and Inhibitor Binding
Chemistry & Biology
2015
22
404-411
Kinetic and Theoretical Studies of Beta-Lactone Reactivity-A Quantitative Scale for Biological Application
ChemPlusChem
2015
80
11
1673-1679
Fimbrolide Natural Products Disrupt Bioluminescence of Vibrio By Targeting Autoinducer Biosynthesis and Luciferase Activity
Angewandte Chemie International Edition
2015
55
1187-1191
Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association
Angewandte Chemie International Edition
2015
54
52
15892-15896
Structure and Mechanism of the Caseinolytic Protease ClpP1/2 Heterocomplex from Listeria monocytogenes
Angewandte Chemie International Edition
2015
54
12
3598-3602
Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues
Angewandte Chemie
2015
127
46
13754-13758