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Titel:

Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Butinar, M; Prebanda, M T; Rajkovi?, J; Jeri?, B; Stoka, V; Peters, C; Reinheckel, T; Krüger, A; Turk, V; Turk, B; Vasiljeva, O
Abstract:
Lysosomal cysteine cathepsins contribute to proteolytic events promoting tumor growth and metastasis. Their enzymatic activity, however, is tightly regulated by endogenous inhibitors. To investigate the role of cathepsin inhibitor stefin B (Stfb) in mammary cancer, Stfb null mice were crossed with transgenic polyoma virus middle T oncogene (PyMT) breast cancer mice. We show that ablation of Stfb resulted in reduced size of mammary tumors but did not affect their rate of metastasis. Importantly,...     »
Zeitschriftentitel:
Oncogene
Jahr:
2014
Band / Volume:
33
Heft / Issue:
26
Seitenangaben Beitrag:
3392-400
Sprache:
eng
Volltext / DOI:
doi:10.1038/onc.2013.314
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23955077
Print-ISSN:
0950-9232
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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