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Title:

Stem Cells and Basic Fibroblast Growth Factor Failed to Improve Tendon Healing

Document type:
Article
Author(s):
Kraus, TM; Imhoff, FB; Wexel, G; Wolf, A; Hirsch, D; Lenz, L; Stöckle, U; Buchmann, S; Tischer, T; Imhoff, AB; Milz, S; Anton, M; Vogt, S
Abstract:
Background: The aim of this controlled study was to investigate the influence of mesenchymal stem cells (MSCs) and lentiviral (LV) expression of basic fibroblast growth factor (bFGF) on tendon remodeling in an in vivo rat model of an Achilles tendon defect. Methods: In eighty-four male Lewis rats, complete 2.4-mm tendon defects were created and were either left untreated (the phosphate-buffered saline solution [PBS] group) or were treated with mesenchymal stem cells expressing enhanced green flu...     »
Journal title abbreviation:
J Bone Joint Surg Am
Year:
2014
Journal volume:
96A
Journal issue:
9
Pages contribution:
761-769
Language:
eng
Print-ISSN:
0021-9355
TUM Institution:
Fachgebiet Sportorthopädie (Prof. Imhoff); Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für Unfallchirurgie
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