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Titel:

The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na? channel, Na(v)1.5.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Schulze, V; Stoetzer, C; O'Reilly, A O; Eberhardt, E; Foadi, N; Ahrens, J; Wegner, F; Lampert, A; de la Roche, J; Leffler, A
Abstract:
Treatment with methadone is associated with severe cardiac arrhythmias, a side effect that seems to result from an inhibition of cardiac hERG K? channels. However, several other opioids are inhibitors of voltage-gated Na? channels. Considering the common assumption that an inhibition of the cardiac Na? channel Na(v)1.5, is the primary mechanism for local anaesthetic (LA)-induced cardiotoxicity, we hypothesized that methadone has LA-like properties leading to a modulation of Na(v)1.5 channels.The...     »
Zeitschriftentitel:
Br J Pharmacol
Jahr:
2014
Band / Volume:
171
Heft / Issue:
2
Seitenangaben Beitrag:
427-37
Sprache:
eng
Volltext / DOI:
doi:10.1111/bph.12465
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24117196
Print-ISSN:
0007-1188
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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