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Title:

Defining the role of common variation in the genomic and biological architecture of adult human height.

Document type:
Journal Article; Article
Author(s):
Wood, Andrew R; Esko, Tõnu; Yang, Jian; Vedantam, Sailaja; Pers, Tune H; Gustafsson, Stefan; Chu, Audrey Y; Estrada, Karol; Luan, Jian'an; Kutalik, Zoltan; Amin, Najaf; Buchkovich, Martin L; Croteau-Chonka, Damien C; Day, Felix R; Duan, Yanan; Fall, Tove; Fehrmann, Rudolf; Ferreira, Teresa; Jackson, Anne U; Karjalainen, Juha; Lo, Ken Sin; Locke, Adam E; Mägi, Reedik; Mihailov, Evelin; Porcu, Eleonora; Randall, Joshua C; Scherag, André; Vinkhuyzen, Anna A E; Westra, Harm-Jan; Winkler, Thomas W; W...     »
Abstract:
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ~2,000, ~3,700 and ~9,500 SNPs explained ~21%, ~24% and ~29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for gen...     »
Journal title abbreviation:
Nat Genet
Year:
2014
Journal volume:
46
Journal issue:
11
Pages contribution:
1173-86
Language:
eng
Fulltext / DOI:
doi:10.1038/ng.3097
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25282103
Print-ISSN:
1061-4036
TUM Institution:
Institut für Humangenetik; Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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