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Titel:

Induced pluripotent stem cell-derived cardiomyocytes for drug development and toxicity testing.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Review; Review
Autor(en):
Sinnecker, Daniel; Laugwitz, Karl-Ludwig; Moretti, Alessandra
Abstract:
Induced pluripotent stem cell (iPSC) technology is creating exciting new opportunities for cardiovascular research by providing platforms to study the mechanisms of disease pathogenesis that could lead to new therapies or reveal drug sensitivities. In this review, the potential usefulness of iPSC-derived cardiomyocytes in drug development as well as in drug toxicity testing is discussed, with a focus on the achievements that have been already made in this regard. Moreover, the crucial steps that...     »
Zeitschriftentitel:
Pharmacol Ther
Jahr:
2014
Band / Volume:
143
Heft / Issue:
2
Seitenangaben Beitrag:
246-52
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.pharmthera.2014.03.004
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24657289
Print-ISSN:
0163-7258
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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