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Title:

Induced pluripotent stem cell-derived cardiomyocytes for drug development and toxicity testing.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review; Review
Author(s):
Sinnecker, Daniel; Laugwitz, Karl-Ludwig; Moretti, Alessandra
Abstract:
Induced pluripotent stem cell (iPSC) technology is creating exciting new opportunities for cardiovascular research by providing platforms to study the mechanisms of disease pathogenesis that could lead to new therapies or reveal drug sensitivities. In this review, the potential usefulness of iPSC-derived cardiomyocytes in drug development as well as in drug toxicity testing is discussed, with a focus on the achievements that have been already made in this regard. Moreover, the crucial steps that...     »
Journal title abbreviation:
Pharmacol Ther
Year:
2014
Journal volume:
143
Journal issue:
2
Pages contribution:
246-52
Language:
eng
Fulltext / DOI:
doi:10.1016/j.pharmthera.2014.03.004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24657289
Print-ISSN:
0163-7258
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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