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Titel:

Adeno-associated viral vector 2.9 thymosin ß4 application attenuates rejection after heart transplantation: results of a preclinical study in the pig.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Postrach, Johannes; Schmidt, Maximilian; Thormann, Michael; Thein, Eckart; Burdorf, Lars; Reichart, Bruno; Sotlar, Karl; Walz, Christoph; Faber, Claudius; Bauer, Andreas; Schmoeckel, Michael; Kupatt, Christian; Hinkel, Rabea
Abstract:
Graft survival is the most important factor for morbidity and mortality in cardiac transplantation. Improved immunosuppression significantly reduced early graft rejection. However, acute rejection may predispose to chronic rejection. Targeting both phases of the recipient's immune-reactivity by means of long-acting recombinant adeno-associated viral vectors (AAVs) encoding anti-inflammatory and cardioprotective factors appears to be a promising therapeutic approach. We investigate thymosin ß4 (T...     »
Zeitschriftentitel:
Transplantation
Jahr:
2014
Band / Volume:
98
Heft / Issue:
8
Seitenangaben Beitrag:
835-43
Sprache:
eng
Volltext / DOI:
doi:10.1097/TP.0000000000000327
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25321165
Print-ISSN:
0041-1337
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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