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- Title:
Comparison of two assays for molecular determination of rifampin resistance in clinical samples from patients with Buruli ulcer disease.
- Document type:
- Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Article
- Author(s):
- Jansson, Moritz; Beissner, Marcus; Phillips, Richard Odame; Badziklou, Kossi; Piten, Ebekalisai; Maman, Issaka; Sarfo, Fred Stephen; Huber, Kristina Lydia; Rhomberg, Agata; Symank, Dominik; Wagner, Magdalena; Wiedemann, Franz; Nitschke, Jörg; Banla Kere, Abiba; Herbinger, Karl-Heinz; Adjei, Ohene; Löscher, Thomas; Bretzel, Gisela
- Abstract:
- This study evaluates a novel assay for detecting rifampin resistance in clinical Mycobacterium ulcerans isolates. Although highly susceptible for PCR inhibitors in 50% of the samples tested, the assay was 100% M. ulcerans specific and yielded >98% analyzable sequences with a lower limit of detection of 100 to 200 copies of the target sequence.
- Journal title abbreviation:
- J Clin Microbiol
- Year:
- 2014
- Journal volume:
- 52
- Journal issue:
- 4
- Pages contribution:
- 1246-9
- Language:
- eng
- Fulltext / DOI:
- doi:10.1128/JCM.03119-13
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/24478404
- Print-ISSN:
- 0095-1137
- TUM Institution:
- Klinik für Anästhesiologie (DHM)
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