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Title:

Tranexamic acid impairs ?-aminobutyric acid receptor type A-mediated synaptic transmission in the murine amygdala: a potential mechanism for drug-induced seizures?

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Kratzer, Stephan; Irl, Hedwig; Mattusch, Corinna; Bürge, Martina; Kurz, Jörg; Kochs, Eberhard; Eder, Matthias; Rammes, Gerhard; Haseneder, Rainer
Abstract:
Tranexamic acid (TXA) is commonly used to reduce blood loss in cardiac surgery and in trauma patients. High-dose application of TXA is associated with an increased risk of postoperative seizures. The neuronal mechanisms underlying this proconvulsant action of TXA are not fully understood. In this study, the authors investigated the effects of TXA on neuronal excitability and synaptic transmission in the basolateral amygdala.Patch clamp recordings and voltage-sensitive dye imaging were performed...     »
Journal title abbreviation:
Anesthesiology
Year:
2014
Journal volume:
120
Journal issue:
3
Pages contribution:
639-49
Language:
eng
Fulltext / DOI:
doi:10.1097/ALN.0000000000000103
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24335749
Print-ISSN:
0003-3022
TUM Institution:
Fachgebiet Kardioanästhesie (Prof. Tassani-Prell); Klinik für Anästhesiologie (DHM)
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