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Titel:

Tranexamic acid impairs ?-aminobutyric acid receptor type A-mediated synaptic transmission in the murine amygdala: a potential mechanism for drug-induced seizures?

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Kratzer, Stephan; Irl, Hedwig; Mattusch, Corinna; Bürge, Martina; Kurz, Jörg; Kochs, Eberhard; Eder, Matthias; Rammes, Gerhard; Haseneder, Rainer
Abstract:
Tranexamic acid (TXA) is commonly used to reduce blood loss in cardiac surgery and in trauma patients. High-dose application of TXA is associated with an increased risk of postoperative seizures. The neuronal mechanisms underlying this proconvulsant action of TXA are not fully understood. In this study, the authors investigated the effects of TXA on neuronal excitability and synaptic transmission in the basolateral amygdala.Patch clamp recordings and voltage-sensitive dye imaging were performed...     »
Zeitschriftentitel:
Anesthesiology
Jahr:
2014
Band / Volume:
120
Heft / Issue:
3
Seitenangaben Beitrag:
639-49
Sprache:
eng
Volltext / DOI:
doi:10.1097/ALN.0000000000000103
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24335749
Print-ISSN:
0003-3022
TUM Einrichtung:
Fachgebiet Kardioanästhesie (Prof. Tassani-Prell); Klinik für Anästhesiologie (DHM)
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