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Title:

The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na? channel, Na(v)1.5.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Schulze, V; Stoetzer, C; O'Reilly, A O; Eberhardt, E; Foadi, N; Ahrens, J; Wegner, F; Lampert, A; de la Roche, J; Leffler, A
Abstract:
Treatment with methadone is associated with severe cardiac arrhythmias, a side effect that seems to result from an inhibition of cardiac hERG K? channels. However, several other opioids are inhibitors of voltage-gated Na? channels. Considering the common assumption that an inhibition of the cardiac Na? channel Na(v)1.5, is the primary mechanism for local anaesthetic (LA)-induced cardiotoxicity, we hypothesized that methadone has LA-like properties leading to a modulation of Na(v)1.5 channels.The...     »
Journal title abbreviation:
Br J Pharmacol
Year:
2014
Journal volume:
171
Journal issue:
2
Pages contribution:
427-37
Language:
eng
Fulltext / DOI:
doi:10.1111/bph.12465
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24117196
Print-ISSN:
0007-1188
TUM Institution:
Klinik für Anästhesiologie (DHM)
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