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Titel:

In Vivo Bioluminescence Imaging of HBV Replicating Hepatocytes Allows for the Monitoring of Anti-Viral Immunity.

Dokumenttyp:
Journal Article
Autor(en):
Manske, Katrin; Schneider, Annika; Ko, Chunkyu; Knolle, Percy A; Steiger, Katja; Protzer, Ulrike; Wohlleber, Dirk
Abstract:
Immunity against hepatitis B virus (HBV) infection is complex and not entirely understood so far, including the decisive factors leading to the development of chronic hepatitis B. This lack of a mechanistic understanding of HBV-specific immunity is also caused by a limited number of suitable animal models. Here, we describe the generation of a recombinant adenovirus expressing an HBV 1.3-overlength genome linked to luciferase (Ad-HBV-Luc) allowing for precise analysis of the quantity of infected...     »
Zeitschriftentitel:
Viruses
Jahr:
2021
Band / Volume:
13
Heft / Issue:
11
Volltext / DOI:
doi:10.3390/v13112273
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34835079
Print-ISSN:
1999-4915
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Virologie ; Roman Herzog Comprehensive Cancer Center
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