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Title:

Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ecker, Veronika; Stumpf, Martina; Brandmeier, Lisa; Neumayer, Tanja; Pfeuffer, Lisa; Engleitner, Thomas; Ringshausen, Ingo; Nelson, Nina; Jücker, Manfred; Wanninger, Stefan; Zenz, Thorsten; Wendtner, Clemens; Manske, Katrin; Steiger, Katja; Rad, Roland; Müschen, Markus; Ruland, Jürgen; Buchner, Maike
Abstract:
Current therapeutic approaches for chronic lymphocytic leukemia (CLL) focus on the suppression of oncogenic kinase signaling. Here, we test the hypothesis that targeted hyperactivation of the phosphatidylinositol-3-phosphate/AKT (PI3K/AKT)-signaling pathway may be leveraged to trigger CLL cell death. Though counterintuitive, our data show that genetic hyperactivation of PI3K/AKT-signaling or blocking the activity of the inhibitory phosphatase SH2-containing-inositol-5'-phosphatase-1 (SHIP1) indu...     »
Journal title abbreviation:
Nat Commun
Year:
2021
Journal volume:
12
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-021-23752-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34112805
Print-ISSN:
2041-1723
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Klinische Chemie und Pathobiochemie; Professur für Translationale gastroenterologische Onkologie (Prof. Rad); Roman Herzog Comprehensive Cancer Center
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