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Title:

Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation.

Document type:
Journal Article
Author(s):
Kabiri, Yaschar; Fuhrmann, Anna; Becker, Anna; Jedermann, Luisa; Eberhagen, Carola; König, Ann-Christine; Silva, Tiago Barros; Borges, Fernanda; Hauck, Stefanie M; Michalke, Bernhard; Knolle, Percy; Zischka, Hans
Abstract:
Augmenter of liver regeneration (ALR) is a critical multi-isoform protein with its longer isoform, located in the mitochondrial intermembrane space, being part of the mitochondrial disulfide relay system (DRS). Upregulation of ALR was observed in multiple forms of cancer, among them hepatocellular carcinoma (HCC). To shed light into ALR function in HCC, we used MitoBloCK-6 to pharmacologically inhibit ALR, resulting in profound mitochondrial impairment and cancer cell proliferation deficits. The...     »
Journal title abbreviation:
Front Cell Dev Biol
Year:
2021
Journal volume:
9
Fulltext / DOI:
doi:10.3389/fcell.2021.725474
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34616733
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Institut für Toxikologie und Umwelthygiene; Roman Herzog Comprehensive Cancer Center
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