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Title:

A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Meiser, Philippa; Knolle, Moritz A; Hirschberger, Anna; de Almeida, Gustavo P; Bayerl, Felix; Lacher, Sebastian; Pedde, Anna-Marie; Flommersfeld, Sophie; Hönninger, Julian; Stark, Leonhard; Stögbauer, Fabian; Anton, Martina; Wirth, Markus; Wohlleber, Dirk; Steiger, Katja; Buchholz, Veit R; Wollenberg, Barbara; Zielinski, Christina E; Braren, Rickmer; Rueckert, Daniel; Knolle, Percy A; Kaissis, Georgios; Böttcher, Jan P
Abstract:
Type 1 conventional dendritic cells (cDC1) can support T cell responses within tumors but whether this determines protective versus ineffective anti-cancer immunity is poorly understood. Here, we use imaging-based deep learning to identify intratumoral cDC1-CD8+ T cell clustering as a unique feature of protective anti-cancer immunity. These clusters form selectively in stromal tumor regions and constitute niches in which cDC1 activate TCF1+ stem-like CD8+ T cells. We identify a distinct populati...     »
Journal title abbreviation:
Cancer Cell
Year:
2023
Journal volume:
41
Journal issue:
8
Pages contribution:
1498-1515.e10
Fulltext / DOI:
doi:10.1016/j.ccell.2023.06.008
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37451271
Print-ISSN:
1535-6108
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski); Institut für KI und Informatik in der Medizin (Prof. Rückert); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene (Prof. Busch); Roman Herzog Comprehensive Cancer Center
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