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Title:

Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection.

Document type:
Article; Journal Article
Author(s):
Kosinska, Anna D; Moeed, Abdul; Kallin, Nina; Festag, Julia; Su, Jinpeng; Steiger, Katja; Michel, Marie-Louise; Protzer, Ulrike; Knolle, Percy A
Abstract:
Therapeutic vaccination against chronic hepatitis B must overcome high viral antigen load and local regulatory mechanisms that promote immune-tolerance in the liver and curtail hepatitis B virus (HBV)-specific CD8 T cell immunity. Here, we report that therapeutic heterologous HBcore-protein-prime/Modified-Vaccinia-Virus-Ankara (MVA-HBcore) boost vaccination followed by CpG-application augmented vaccine-induced HBcAg-specific CD8 T cell-function in the liver. In HBV-transgenic as well as AAV-HBV-...     »
Journal title abbreviation:
Sci Rep
Year:
2019
Journal volume:
9
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41598-019-47149-w
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31346211
Print-ISSN:
2045-2322
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Virologie ; Roman Herzog Comprehensive Cancer Center
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