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Title:

Does Anticoagulant Medication Alter Fracture-Healing? A Morphological and Biomechanical Evaluation of the Possible Effects of Rivaroxaban and Enoxaparin Using a Rat Closed Fracture Model.

Document type:
Journal Article
Author(s):
Prodinger, Peter Michael; Burgkart, Rainer; Kreutzer, Kilian; Liska, Franz; Pilge, Hakan; Schmitt, Andreas; Knödler, Martina; Holzapfel, Boris Michael; Hapfelmeier, Alexander; Tischer, Thomas; Bissinger, Oliver
Abstract:
Low molecular weight heparin (LMWH) is routinely used to prevent thromboembolism in orthopaedic surgery, especially in the treatment of fractures or after joint-replacement. Impairment of fracture-healing due to increased bone-desorption, delayed remodelling and lower calcification caused by direct osteoclast stimulation is a well-known side effect of unfractioned heparin. However, the effect of LMWH is unclear and controversial. Recent studies strongly suggest impairment of bone-healing in-vitr...     »
Journal title abbreviation:
PLoS ONE
Year:
2016
Journal volume:
11
Journal issue:
7
Pages contribution:
e0159669
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0159669
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27455072
Print-ISSN:
1932-6203
TUM Institution:
Fachgebiet Sportorthopädie (Prof. Imhoff); Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie; Klinik und Poliklinik für Orthopädie und Sportorthopädie
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