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Title:

Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma.

Document type:
Journal Article
Author(s):
Wagner, Ferdinand; Holzapfel, Boris M; McGovern, Jacqui A; Shafiee, Abbas; Baldwin, Jeremy G; Martine, Laure C; Lahr, Christoph A; Wunner, Felix M; Friis, Thor; Bas, Onur; Boxberg, Melanie; Prodinger, Peter M; Shokoohmand, Ali; Moi, Davide; Mazzieri, Roberta; Loessner, Daniela; Hutmacher, Dietmar W
Abstract:
BACKGROUND: Existing preclinical murine models often fail to predict effects of anti-cancer drugs. In order to minimize interspecies-differences between murine hosts and human bone tumors of in vivo xenograft platforms, we tissue-engineered a novel orthotopic humanized bone model. METHODS: Orthotopic humanized tissue engineered bone constructs (ohTEBC) were fabricated by 3D printing of medical-grade polycaprolactone scaffolds, which were seeded with human osteoblasts and embedded within polyethy...     »
Journal title abbreviation:
Biomaterials
Year:
2018
Journal volume:
171
Pages contribution:
230-246
Language:
eng
Fulltext / DOI:
doi:10.1016/j.biomaterials.2018.04.030
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29705656
Print-ISSN:
0142-9612
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Orthopädie und Sportorthopädie
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